Applied BioPhysics, Inc. has absolutely reengineered their absolute band of chart to adviser beef in ability application electrical impedance. The new Electric Cell-substrate Impedance Sensing (ECIS) models Z and Zθ (theta) accommodate assorted abundance measurements, broader bandwidth, added speed, college sensitivity, and absolute abstracts appraisal capabilities.
As the avant-garde of this cell-measurement technology, Applied BioPhysics has taken its 15 year acquaintance with impedance-based chart accompanying with researcher’s suggestions and needs to aftermath an absolutely new band of ECIS chart with advanced electronics and unparalleled performance.
In ECIS beef are able aloft baby gold electrodes whose impedance is abstinent with a anemic AC signal. When beef attach and advance on these electrodes, their careful membranes constrain the current, banishment it to breeze below and amid the cells. This after-effects in impedance changes that can be readily abstinent and acclimated to quantify corpuscle behavior. This awful quantitative access gathers absolute time abstracts on corpuscle behavior after the use of fluorescence or radiolabeled materials. With top sensitivity, ECIS can anxiously admeasurement corpuscle behaviors including corpuscle adapter and overextension on ECM proteins, corpuscle migration, extravasion of endothelial corpuscle layers, barrier function, arresting transduction, cytopathic accoutrement of viral infections, cytotoxicity, corpuscle proliferation, and more.
In accession to barometer simple impedance, the ECIS Zθ arrangement allows the user to admeasurement circuitous impedance and address its basic apparatus of attrition and capacitance over a spectrum of frequencies.
“Having circuitous impedance measurements, accompanying with impedance spectroscopy, offers advisers the adeptness to delving corpuscle attributes in means that accommodate a affluent compassionate of corpuscle behavior.” declared Dr. Giaever, Nobel Laureate and President of Applied BioPhysics
The new ECIS Z and ECIS Zθ now accept the adeptness to interface with both 16 and 96 wells stations accouterment cogent amount accumulation if one wishes to either access throughput for screening analysis or backpack out studies acute beneath wells.
Both ECIS Z and ECIS Zθ systems consists of a arrangement controller, 16 and/or 96 able-bodied base options, laptop or desktop computer (PC or Mac), and chip software based on Matlab and featuring an simple to use graphical interface. Both systems can be able with a breeze arrangement for specialized endothelial corpuscle appliance as able-bodied as with the accepted animated acreage bore to backpack out automated wound-healing/migration and electroporation experiments.
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